Reverse vaccinology – the key to novel antigens

The basic idea behind Reverse Vaccinology is that an entire pathogenic genome can be screened using bioinformatics approaches to find genes. Next, those genes are filtered for desirable attributes that would make good vaccine targets such as outer membrane proteins. Those proteins then undergo normal wet lab testing for immune responses. The term was coined by Dr Rino Rappuoli, now …

2020 vision for vaccines against HIV, tuberculosis and malaria

Rino Rappuoli, PhD, is Global Head of Vaccines Research at Novartis Vaccines and Diagnostics and is based in Siena, Italy.   In one of his most recent publications in Nature together with Alan Aderem, they discuss their 2020 vision for vaccines against HIV, tuberculosis and malaria.   Acquired immune deficiency syndrome (AIDS), malaria and tuberculosis collectively cause more than five …