Immunome-Derived vaccines- Dr Timothy Messitt EpiVax World Vaccine Congress

Written by on February 11, 2013 in Featured Videos, Prophylactic Vaccines, R&D with 0 Comments

Vaccine design: what’s next?

Last April Dr Timothy Messitt from EpiVax delivered a presentation about the next wave of vaccine design on immune-derived vaccines at the World Vaccine Congress Washington.

See below the key highlights of his presentation:

Immunome-derived are T cell epitope driven vaccines that were developed in order to improve safety (limited potential for autoimmunity) and immunogenicity. Would like to take this into biodefense portfolio.

The focus is on T cell epitopes being able to predict T cell epitopes (Class 1 and 2 MHC binding) using EpiMatrix. The process goes through the following phases:

1. T cell epitope identification:
â– CLUSTIMERS (identifies epitope clusters); potent epitops are promiscuous
â– CONSERVATRIX finds conserved 9mers to be able to protect against as many strains possible
â– Removal of cross-reactive epitopes

2. Expressing epitopes, usually by DNA plasmids followed with peptide boost; optimized whole proteins or VLPs with iso-optimized proteins

3. In vivo evaluation by HLA binding assays

Current vaccines: Burk/Tuly/MP, HIV/TB, Smallpox (VennVax) and others

The company is focusing on an accelerated vaccine approach focusing on biodefense and is planning to integrate all technologies in a web-based toolkit, iVax (currently beta testing it).

Dr Timothy Messitt, Manager, Business Development, EpiVax

Visit our Website: http://www.terrapinn.com/2013/world-vaccine-congress-washington/index.stm
Read our blog: http://blogs.terrapinn.com/vaccinenation/
Follow us on Twitter: @vaccinenation
Join our Linkedin group: http://www.linkedin.com/groups/Vaccine-Nation-1351197

Tags: ,

About the Author

About the Author: Marketing Manager for Terrapinn's lifescience events #vaccines #syntheticbiology #raredisease #antibodies #biosimilars #stemcells #cellculture #HPAPI .

Subscribe

If you enjoyed this article, subscribe now to receive more just like it.

Subscribe via RSS Feed Connect on Google Plus Join Our LinkedIn Group Connect on YouTube
Top
Geolocation