Martin Richter, Associate Professor, Department of Medicine at Centre de Recherche Clinique Ã‰tienne-Le Bel, kindly provided this link to an interesting article, entitled â€˜Initial infectious dose dictates the innate, adaptive, and memory responses to influenza in the respiratory tract,’ originally published in the Journal of Leukocyte Biology.
Several viral factors contribute to influenza virulence in the host, but similarly several host factors can also contribute to virus virulence.
This article examines the effects of an initial infectious dose of virus, and outlines “new findings concerning the antiviral and inflammatory responses, innate and adaptive immunity, memory responses, and protection against secondary heterologous infection.”
The authors argue that “the initial infectious dose of influenza determines the development of several aspects of antiviral immunityâ€¦[providing] new insights on virus-host interaction in the generation of the global immune response to influenza.”
For more detailed information on the study, including methodology, findings and implications, read the full article now.
Martin will be speaking at the upcoming Influenza Congress USA event, taking place in Washington, D.C. this November. He will present on the topic, â€˜Viral load, inflammation and the generation of T Cell memory.’ Download the brochure for more information.