Download: Retroscreen Virology paper on preexisting influenza-specific CD4+ T cells and correlation with disease protection

Retroscreen Virology kindly provided this whitepaper, entitled ‘Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans.’

Download the whitepaper here.

In the paper, the authors suggest that “protective immunity against influenza virus infection is mediated by neutralizing antibodies, but the precise role of T cells in human influenza immunity is uncertain.”

Because of this, they undertook an influenza infection study, where they mapped T cell responses to influenza before and during infection. They found that “preexisting CD4+, but not CD8+, T cells responding to influenza internal proteins were associated with lower virus shedding and less severe illness,” and “these CD4+ cells also responded to pandemic H1N1 […] peptides and showed evidence of cytotoxic activity.”

The authors go on to suggest that “these cells are an important statistical correlate of homotypic and heterotypic response and may limit severity of influenza infection by new strains in the absence of specific antibody responses. [These] results provide information that may aid the design of future vaccines against emerging influenza strains.”

The whitepaper discusses in more detail:

  • Human influenza infection model
  • Antibody and T cell responses
  • Preexisting T cell responses, viral shedding and symptom scores
  • Preexisting T cells against nucleoprotein and matrix protein
  • Heterosubtypic memory CD4+ T cell responses

For more information on this, make sure you download the whitepaper now.

Rob Lambkin-Williams, Chief Scientific Officer of Retroscreen Virology, will be speaking at the upcoming Influenza Congress USA conference on the topic, ‘Conducting human viral challenge studies to address patient recruitment difficulties.’ Retroscreen Virology is a sponsor of this event.

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