Presentation download: Improving influenza vaccines: enhanced immunogenicity with MF59® adjuvant

download, influenza vaccine development, novartis


Dr Niranjan Kanesa-thasan, Head of External Collaborations and Special Projects, Novartis Vaccines & Diagnostics, joined us at the World Vaccine Congress in Washington in 2012 to present research into how to improve influenza vaccines through the addition of the MF59® adjuvant. In his presentation, Dr Kanesa-thasan discusses the effects of the adjuvant on immunogenicity and efficacy, its safety profile and sparing doses and synthetic vaccine seeds to increase vaccine supplies.

Predominantly, MF59® acts at the injection site to trigger a strong and broad vaccine-specific immune response. Non-ajuvanted TIVs have been shown to offer up to 60% protection from influenza illness. The effectiveness of TIV could be reduced by age-related immune vulnerability and by a mismatch of circulating strains. With the addition of The MF59® into the influenza vaccine, a higher immune response was induced when compared to those of the non-adjuvanted TIV. It also demonstrated a vaccine efficacy of 86% against all circulating strains.

Why not download the full presentation and discover more about improving influenza vaccines:

· Boosting titers, increasing breadth of response against drifted influenza strains

· Safety record of the MF59 adjuvant

· Sparing doses to increase vaccine supplies


Download the full presentation here!

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