Dr Marian Major, Research Microbiologist, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research at FDA joined us a few weeks ago at the 12th annual World Vaccine Congress in Washington DC to discuss about the challenges and perspectives on Hepatitis C Vaccines.
Challenges to HCV Vaccine Development
ï Natural isolates exist as quasispecies populations. Several genotypes identified (GT 1-6).
ï Greatest diversity in natural isolates is observed in the envelope region.
ï Only animal model for HCV pathogenesis is the chimpanzee
ï Biomarkers of protection still need to be identified. Cross reactive neutralizing antibodies have been identified but T-cell phenotypes important for
protection have not been determined.
For the whole presentation and details on the above mentioned focus points, please download the presentation here.